The ramp from Stamford New Road to Stamford Square is to close for around seven months to allow for the "transformation" of the Stamford Square public realm.
The ramp - a popular gateway between Altrincham Interchange and Stamford Square - is to close on January 2nd.
Several months of enhancements will then begin that are designed to improve accessibility, provide space for community activity and offer a more welcoming environment for visitors.
The work will take in part of George Street, Stamford Square, the ramp leading to Altrincham Interchange and the pavement outside Foundation on Stamford New Road.
Completion is expected in July 2024, and all businesses in the area will remain open throughout the works.
The work is part of the Stamford Quarter's regeneration of the northern end of George Street and complete reimagining of the former Rackhams department store into 50,000 sq ft of commercial workspace and 25,000 sq ft of retail and leisure space.
Bowling brand Lane7 has previously been announced as the first leisure operator at Foundation, while global sports marketing agency SPORTFIVE will be the first corporate tenant.
The transformative development will include a 375 sq m living biophilic wall on the building’s external façade, made up of 36,000 carefully selected plants grown by local firm I Want Plants, reducing the building’s carbon emissions and creating a habitat for wildlife.